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KMID : 0383820150780020112
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Tuberculosis and Respiratory Diseases
2015 Volume.78 No. 2 p.112 ~ p.119
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A Rare Case of Primary Thymic Adenocarcinoma Mimicking Small Cell Lung Cancer
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Cho Eun-Na
Park Hye-Sung
Kim Tae-Hoon
Byun Min-Kwang
Kim Hyung-Jung
Ahn Chul-Min
Chang Yoon-Soo
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Abstract
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Primary thymic adenocarcinoma is a very rare malignancy of the anterior mediastinum with no standardized treatment. A 36-year-old male patient presented with hoarseness over the past 3 months. A chest computed tomography (CT) scan showed an infiltrative mass to the proximal vessels and aortic arch in left upper mediastinum (4.1×3.1×5.4 cm). Brain magnetic resonance imaging (MRI) showed focal lesions, suggesting metastasis in the left frontal lobe. A thoracoscopic biopsy of the mediastinal mass confirmed a primary thymic adenocarcinoma forming a glandular structure with atypia of tumor cells. The patient received four cycles of systemic chemotherapy, consisting of etoposide and cisplatin, with concurrent radiotherapy (6,000 cGy/30 fractions) to the mediastinal lesion and the metastatic brain lesion (4,200 cGy/12 fractions). A follow-up chest CT scan and brain MRI showed a decrease in the size of the left upper mediastinal mass and brain lesion. We report a rare case of the primary thymic adenocarcinoma with a literature review.
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KEYWORD
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Adenocarcinoma, Thymus, Concurrent Chemoradiotherapies
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